Nowadays, decarbonization of the shipping industry has become the top priority of the maritime community. In an effort to reduce emissions from shipping, numerous tech-nological and design solutions are being investigated; Waste Heat Recovery (WHR) by marine engines is one of the most important and widespread ones. This paper investi-gates the utilization of a carbon dioxide Supercritical Brayton Cycle (SBC) for WHR of a LNG carrier. SBC is an innovative, promising technology for power generation with unprecedented performance and a small form factor, due to the properties of the working fluid. A thermodynamic model is developed and programmed in MATLAB using the CoolProp free library. By means of this model, the performance of simple and recuperated SBC (RSBC) for WHR of a specific marine engine at its full load operation is assessed and the optimum compressor pressure ratio for power maximization of the RSBC is selected. The combined system Diesel-RSBC exhibits an increase of about 2.9% in thermal efficiency and a similar reduction in specific fuel oil consumption, com-pared to the sole power production by the Diesel engine, at its full load operation. Sig-nificant performance benefits are also demonstrated at part-load operation of the main engine. To assess how the benefits scale with the main engine power, seven similar marine engines of different power are considered, revealing a possible relationship between the optimal pressure ratio and SBC efficiency with the engine’s exhaust gas temperature.