This article proposes a General Theory of Pluriversal Knowledge (GTPK), advancing beyond classical epistemology, postcolonial critique, and relativist pluralism. It argues that contemporary global crises—ecological, epistemic, technological, and civilisational—are fundamentally knowledge-structural failures produced by hierarchical, monocentric epistemic regimes. Drawing on complexity science, systems theory, indigenous epistemologies, philosophy of science, and meta-intelligence frameworks, the article develops a formal theory explaining how multiple knowledge worlds can coexist without hierarchy while remaining operationally coherent. The concept of pluriversal coherence is introduced as a foundational principle enabling epistemic interoperability across ontologically distinct knowledge systems. The theory reframes knowledge not as representation but as relational enactment across plural realities. The article concludes by outlining implications for science, governance, AI, education, and African and Global South knowledge futures.