The increasing adoption of Microservices Architecture (MSA) and Cloud Computing offers significant agility but introduces substantial challenges for traditional Business Process Compliance (BPC). This paper addresses these challenges using a Design Science Research Methodology (DSRM). We identify persistent research gaps, including a “Broken Feedback Loop” between design-time and runtime systems. To address these gaps, we present BPC4MSA, a cloud-native framework for holistic BPC management spanning the full lifecycle—from design-time verification to resilient, asynchronous runtime auditing—derived from systematic requirements analysis. This work’s primary contribution is the BPC4MSA framework, a novel conceptual artifact whose design theoretically addresses these gaps. We evaluate this design via a dual-method approach: first, a Systematic Literature Review confirms the framework’s conceptual novelty against the state-of-the-art. Second, a preliminary empirical study of a runtime prototype component is conducted not as a performance benchmark, but as a feasibility check. This check confirms the expected architectural trade-offs of its event-driven pattern, validating its suitability for asynchronous auditing use cases and highlighting critical implementation challenges, such as consumer scaling.